Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression
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منابع مشابه
TITLE: Is Peripheral Benzodiazepine Receptor (PBR) Gene Expression Involved in Breast Cancer Suppression by Dietary Soybean Protein? PRINCIPAL INVESTIGATOR:
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متن کاملPeripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol.
Aberrant cell proliferation and increased invasive and metastatic behavior are hallmarks of the advancement of breast cancer. Numerous studies implicate a role for cholesterol in the mechanisms underlying cell proliferation and cancer progression. The peripheral-type benzodiazepine receptor (PBR) is an Mr 18,000 protein primarily localized to the mitochondria. PBR mediates cholesterol transport...
متن کاملPBR-mediated Cell Proliferation and Nuclear Transport of Phenotype with PBR Expression, Nuclear Localization, and Breast Cancer : Correlation of Breast Cancer Cell Aggressive Peripheral-Type Benzodiazepine Receptor (PBR) in Human
Aberrant cell proliferation and increased invasive and metastatic behavior are hallmarks of the advancement of breast cancer. Numerous studies implicate a role for cholesterol in the mechanisms underlying cell proliferation and cancer progression. The peripheral-type benzodiazepine receptor (PBR) is an Mr 18,000 protein primarily localized to the mitochondria. PBR mediates cholesterol transport...
متن کاملPK11195, A PERIPHERAL BENZODIAZEPINE RECEPTOR (PBR) LIGAND, BROADLY BLOCKS DRUG EFFLUX TO CHEMOSENSITIZE LEUKEMIA AND MYELOMA CELLS BY A PBR-INDEPENDENT, DIRECT TRANSPORTER- MODULATING MECHANISM Running head: PK11195 broadly blocks drug efflux to chemosensitize hematologic cancer cells
Acknowledgements: This work was supported in part by a grant from the NCI (CA 89491, Dr. Deborah Banker, PI). We recognize the critical help of the FHCRC Large-Scale Cell Processing Core (Dr. Shelley Heimfeld, PI) and the Vector Production and Tracking Core (Dr. Hans-Peter Kiem, PI) that are supported by NIH DK 56465, Core Center of Excellence in Molecular Hematology grant (Dr. Beverly Torok-St...
متن کاملAntimitotic activity of high affinity ligands for peripheral benzodiazepine receptor (PBR) in some normal and neoplastic cell lines.
PURPOSE Overexpression of PBR has been found in several tumor types including ovarian, colon, breast adenocarcinomas, esophageal cancer. There is evidence suggesting that PBR ligands regulate cell proliferation. However, their action is probably cell-type specific. We decided to evaluate mitotic activity of PBR ligands in some normal and neoplastic cell lines. MATERIAL AND METHODS The cells w...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2005
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2004.11.029